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Year : 2018  |  Volume : 20  |  Issue : 3  |  Page : 157-161

The effect of positive airway pressure therapy on lipid profile

1 Department of Pulmonary Diseases, Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey
2 Department of Pulmonary Diseases, Istanbul Medeniyet University, Istanbul, Turkey
3 Department of Otorhinolaryngology Head and Neck Surgery, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey

Correspondence Address:
Dr. Ahmet Cemal Pazarli
Department of Pulmonary Diseases, Faculty of Medicine, Gaziosmanpasa University, Tokat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejop.ejop_25_18

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CONTEXT: Obstructive sleep apnea syndrome (OSAS) emphasize the concurrence and interaction of disorders of lipid metabolism and components of metabolic syndrome (MS) such as insulin resistance. AIMS: The aim of this study is to observe the effect of positive airway pressure (PAP) treatment on the lipid profile during 1-year follow-up of patients diagnosed with OSAS. SETTINGS AND DESIGN: This was a single-center, retrospective, observational study. MATERIALS AND METHODS: A total of 168 OSAS patients were diagnosed in our sleep laboratory and were recommended for PAP therapy. Among these patients, 64 patients who received effective PAP treatment for 1 year, and who did not have the comorbid disease, history of lipid-lowering treatment, or history of lifestyle change, dietary regulation or attempt to loose weight during the 1-year follow-up period were included in the study. Pretreatment measurement parameters including body weight, waist, neck and hip circumference, body mass index (BMI), blood lipid levels (total cholesterol [TC], triglyceride [TG], high-density lipoprotein [HDL], low-density lipoprotein [LDL]), and Epworth sleepiness scale (ESS) score were compared with the 3rd and 12th months parameters. STATISTICAL ANALYSIS USED: SPSS version 16 (SPSS Inc., Chicago, IL, USA) was used for the statistical analyses. RESULTS: The study included 64 (38 M, 26 F) patients (mean age of 53.1 years). The mean apnea-hypopnea index was 50.84 h. Although TC, HDL, LDL, and TG levels did improve with the PAP treatment (all P < 0.05), no significant decrease was observed with respect to the BMI, hip, neck, and waist circumference (all P > 0.05). There were statistically significant changes in sleep efficiency, oxygen desaturation index, and ESS score (P < 0.05). CONCLUSIONS: The results show that effective PAP treatment has beneficial effects on the blood lipid profile, which enhances sleep efficiency and sleep quality in patients.

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