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| LETTER TO EDITOR |
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| Year : 2019 | Volume
: 21
| Issue : 1 | Page : 79 |
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Effect of sputum bacteriology on the prognosis of patients with acute exacerbations of bronchiectasis in the intensive care unit
Fatma Ciftci, Deniz Dogan Mülazimoglu, Serhat Erol, Aydin Ciledag, Akin Kaya
Department of Chest Disease, Ankara University School of Medicine, Ankara, Turkey
| Date of Submission | 05-Dec-2018 |
| Date of Decision | 06-Dec-2018 |
| Date of Acceptance | 06-Dec-2018 |
| Date of Web Publication | 30-Apr-2019 |
Correspondence Address:
Dr. Fatma Ciftci
Department of Chest Disease, Ankara University School of Medicine, Ankara
Turkey
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/ejop.ejop_73_18
How to cite this article:
Ciftci F, Mülazimoglu DD, Erol S, Ciledag A, Kaya A. Effect of sputum bacteriology on the prognosis of patients with acute exacerbations of bronchiectasis in the intensive care unit. Eurasian J Pulmonol 2019;21:79 |
How to cite this URL:
Ciftci F, Mülazimoglu DD, Erol S, Ciledag A, Kaya A. Effect of sputum bacteriology on the prognosis of patients with acute exacerbations of bronchiectasis in the intensive care unit. Eurasian J Pulmonol [serial online] 2019 [cited 2020 Jul 4];21:79. Available from: http://www.eurasianjpulmonol.com/text.asp?2019/21/1/79/257456 |
Dear Authors,
We are grateful for all your comments and suggestions about the results of our research.[1] We think that the results of this study are important because of the involvement of patients with severe bronchiectasis exacerbation and respiratory failure who were admitted to the intensive care unit (ICU). This was a special group of patients because nearly 90% of cases needed mechanical ventilation. There is limited information about the outcomes of patients with bronchiectasis admitted to the ICU. Our study primarily aimed to determine bacteriologic microorganisms in the sputum, the need for invasive ventilation, and mortality during ICU follow-up, which were collectively labeled as therapy failure. We strongly agree with your opinion about the importance of strict infection control in ICU. Infections which were acquired in ICU are still one of the most important causes of in-hospital mortality.[2] However, in this study, sputum samples were collected at ICU admission before antibiotic administration. Therefore, the infectious microorganisms proliferated in the sputum culture were not acquired from ICU. Sputum samples were carried out with Gram staining; cultures were evaluated quantitatively and contamination was excluded. As mentioned in the manuscript, factors such as age, sex, general characteristics, comorbid diseases, and radiological prevalence of the disease were also evaluated. According to our study results, there was no statistically significant correlation between all these factors and therapy failure. To the best of our knowledge, bacterial infections have a negative effect on the clinical presentation of bronchiectasis patients.[3] The primary aim of this study was to determine the role of sputum culture for the prediction of the prognosis of bronchiectasis patients with respiratory failure. Therefore, the most significant factors of treatment failure were included in the univariate model, and a multivariate analysis revealed bacterial proliferation in sputum culture as the independent risk factor for prognosis in ICU. The results of this study demonstrate the importance of bacterial culture positivity for prognosis in the same way as similar studies.[4]
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| References | |  |
| 1. | Ciftci F, Mülazimoglu DD, Erol S, Çiledag A, Kaya A. Effect of sputum bacteriology on the prognosis of patients with acute exacerbations of bronchiectasis in the intensive care unit. Eurasia J Pulmonol 2018;20:85-9.  |
| 2. | Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the infectious diseases society of America and the American Thoracic Society. Clin Infect Dis 2016;63:e61-111. |
| 3. | Davies G, Wells AU, Doffman S, Watanabe S, Wilson R. The effect of Pseudomonas aeruginosa on pulmonary function in patients with bronchiectasis. Eur Respir J 2006;28:974-9. |
| 4. | Dupont M, Gacouin A, Lena H, Lavoué S, Brinchault G, Delaval P, et al. Survival of patients with bronchiectasis after the first ICU stay for respiratory failure. Chest 2004;125:1815-20. |
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