• Users Online: 318
  • Print this page
  • Email this page
Year : 2020  |  Volume : 22  |  Issue : 1  |  Page : 42-47

Using fractional exhaled nitric oxide level to differentiate asthma–COPD overlap syndrome from chronic obstructive pulmonary disease

1 Department of Chest Diseases, Medicana Konya Hospital, Konya, Turkey
2 Department of Chest Diseases, Medicine School, Selçuk University, Konya, Turkey
3 Department of Public Health, Medicine School, Selçuk University, Konya, Turkey

Correspondence Address:
Dr. Volkan Taskin
Department of Chest Diseases, Medicana Konya Hospital, Konya
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejop.ejop_29_19

Rights and Permissions

INTRODUCTION: Measurement of fractional exhaled nitric oxide (FeNO) is a simple, noninvasive, reproducible, and convenient method for assessing airway inflammation. We here assessed the value of FeNO for distinguishing asthma-COPD overlap syndrome (ACOS) and chronic obstructive pulmonary disease (COPD) in patients hospitalized due to exacerbation of COPD. METHODS: A total of 100 consecutive patients diagnosed with COPD and hospitalized due to disease exacerbation were included and divided into the COPD-alone group and ACOS group. FeNO was measured at the beginning of hospitalization and at discharge. RESULTS: There was no correlation between FeNO values measured at the time of hospitalization and hospital duration (r = −0.10, P = 0.334). However, the mean FeNO value at the beginning of hospitalization was significantly higher in the ACOS group than in the COPD-alone group (25.5 [11–149] vs. 13.0 [5–50]; P < 0.001). The initial FeNO value was a good predictor of ACOS, with an optimum value of 18.5 parts per billion (sensitivity, 80%; specificity, 80%; positive and negative predictive values, 63.6% and 90.6%, respectively). CONCLUSION: The FeNO level can identify ACOS in patients hospitalized for COPD exacerbation, providing a new diagnostic tool for the clinical management of ACOS and COPD.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded33    
    Comments [Add]    

Recommend this journal