• Users Online: 703
  • Print this page
  • Email this page


 
 
Table of Contents
ORIGINAL ARTICLE
Year : 2020  |  Volume : 22  |  Issue : 1  |  Page : 59-63

The effects of preoperative pulmonary rehabilitation on early postoperative period following lung transplantation


1 Department of Physical Therapy and Rehabilitation, Faculty of Health Sciences, University of Health Sciences, Istanbul, Turkey
2 Department of Pulmonary Rehabilitation, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
3 Department of Chest Diseases, Memorial Şişli Hospital, Istanbul, Turkey

Date of Submission24-Jun-2019
Date of Decision19-Jul-2019
Date of Acceptance23-Jul-2019
Date of Web Publication30-Apr-2020

Correspondence Address:
Dr. Esra Pehlivan
Hürriyet Mh, Rüya Sk, No: 12 D: 12 Bahçelievler, Istanbul
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejop.ejop_54_19

Rights and Permissions
  Abstract 


CONTEXT: Although pulmonary rehabilitation (PR) has become a preoperative standard practice, the fact that studies do not include groups of patients who do not receive preoperative PR restricts to introduce the real benefit of the rehabilitation process in lung transplantation (LTx).
AIMS: We aimed to investigate the effect of preoperative PR before LTx on postoperative period.
SETTINGS AND DESIGN: Retrospective, parallel design.
SUBJECTS AND METHODS: Between March 2012 and October 2014, medical records of patients who underwent LTx were analyzed. There were two parallel groups. (1) Study group (n = 15) included the patients with received preoperative PR for at least 8 weeks. (2) Control group (n = 12) included the patients with underwent LTx without preoperative PR as appropriate donor was found. Time to intubation, length of intensive care unit (ICU) stay, and postoperative early mortality were evaluated.
STATISTICAL ANALYSIS USED: Shapiro–Wilk, Fisher' exact test, Mann–Whitney U-test, Wilcoxon rank test.
RESULTS: A total of 27 patients with LTx surgery, whose mean age was 40.6 (11.4) and 40% of females were included in the study. There were no significant differences in demographic characteristics between two groups, except the age (P = 0.005). The study group intubation time (2 [0–7] days) was shorter than control group (3 [1–12] days) (P = 0.02). There was no significant difference in the length of ICU stay postoperatively (P = 0.19) and postoperative early mortality rate (P = 0.65).
CONCLUSIONS: Our study results suggest that preoperative PR may shorten time to intubation in patients undergoing LTx. Therefore, referral of LTx to PR centers and preoperative PR is of utmost importance for postoperative LTx.

Keywords: Intensive care, intubation, lung transplantation


How to cite this article:
Pehlivan E, Kılı L, Balcı A, Yazar E, Bakan ND. The effects of preoperative pulmonary rehabilitation on early postoperative period following lung transplantation. Eurasian J Pulmonol 2020;22:59-63

How to cite this URL:
Pehlivan E, Kılı L, Balcı A, Yazar E, Bakan ND. The effects of preoperative pulmonary rehabilitation on early postoperative period following lung transplantation. Eurasian J Pulmonol [serial online] 2020 [cited 2020 Oct 19];22:59-63. Available from: https://www.eurasianjpulmonol.com/text.asp?2020/22/1/59/283631




  Introduction Top


Pulmonary rehabilitation (PR) is one of the most important components in the treatment of chronic respiratory patients.[1] It is also know that preoperative PR is beneficial in the thoracic surgery process.[2],[3],[4],[5] It has been shown in the literature that preoperative chest physiotherapy increase oxygen saturation, reduce hospital stay in patients with thoracotomy.[2] Lung transplantation (LTx) is one of the most difficult procedures in thoracic surgery. It can be predicted that preoperative PR, which has proven successful in other thoracic surgery procedures, will positively affect patients' clinical status in LTx process. However, there is limited number of studies about this issue.

The originality of our study is that there was a control group that did not undergo preoperative PR. As it is not ethical to create a group that does not undergo preoperative PR as a random, our control group was spontaneously formed as appropriate donors were found which allowed us to examine the effect of preoperative PR on LTx. Therefore, in the present study, we aimed to investigate the effect of preoperative PR for 8 weeks in the supervised outpatient PR program before LTx on postoperative period.


  Subjects and Methods Top


Between March 2012 and October 2014, records of 27 patients who underwent LTx in… Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital were retrospectively reviewed. Fifteen patients were admitted to the regular PR training program for at least 8 weeks in the transplant waiting period and called study group. Twelve patients were operated without being included in the PR program due to the availability of donors earlier and called control group. Ethics approval was obtained from Local Ethic Committee and was conducted in accordance with the Helsinki Declaration. The study flow chart was given in [Figure 1].
Figure 1: Study flow chart

Click here to view


The study group could be evaluated at the beginning and at the end of the PR in the preoperative period. The 6-min walking test was performed to assess functional capacity following the American Thoracic Society Guidelines.[6] Participants walked along an enclosed 30-m corridor and were instructed to walk at their own pace to cover as much distance as possible in 6 min. The patient's walking distance and Borg scores were recorded. Dyspnea perceptions during the activities of daily living was assessed with Medical Research Council Scale.[7] In addition, the distance covered by ergometers during exercise training was noted.

In addition, the patient' intraoperative anesthesia and total ischemia duration, the duration of mechanic ventilation and stay in intensive care unit (ICU), and mortality rates (including 1 month) were retrospectively recorded in both the groups.

Exercise program

The study group underwent a preoperative PR exercise program for 8 weeks, 2 days/week in the hospital, and 3 days at home. The exercise program included breathing exercises, upper and lower extremity strengthening, and aerobic exercises. Diaphragmatic breathing and lateral basal breathing exercises were taught as breathing exercises. There were treadmill walking (15 min/day), bicycle (15 min/day), and arm ergometer (15 min/day) in aerobic exercises in hospital. The aerobic exercise workload was calculated using the target heart rate method and at least 60% of the maximal heart rate. Free weights were used for strengthening exercises. The load was increased progressively with respect to tolerance by starting with 20% of the maximum one repetition weight calculated.

In addition to the supervised exercise program that was administered on 2 days at the hospital, the patients were asked to perform the home exercise program for 3 days a week. The program included breathing exercises, free walking, upper and lower extremity strengthening exercises with Thera-Band. A follow-up form was given, and weekly chart follow-ups were performed by the responsible physiotherapist.

Both groups underwent chest physiotherapy in the postoperative ICU. Passive in-bed mobilizations and positioning were done if the patients were to be sedated. If the clinical status was awake, respiratory exercises, assisted coughing, percussion, and gradual mobilization were performed from the 1st day as soon as the clinical conditions were stabilized.

Statistical analysis

Statistical analysis was performed using Statistical Package for Social Sciences (SPSS) version IBM Statistic 15.0 (SPSS Inc., Chicago, IL, USA). The normalizations of the data were examined using the Shapiro–Wilk test (P >0.05). If the data were distributed normally, it was expressed as “mean (standard deviation)” and if it is not normally distributed, it is expressed as “median (minimum-maximum).” The categorical variables were expressed as percentage (%). Wilcoxon signed-ranks test was used for the comparison of the pre- and post-treatment measurable values of the same group. The Mann–Whitney U-test performed to test the significance of pairwise differences between groups. The analysis of categorical data was performed using Chi-square and Fisher's exact tests. P < 0.05 is considered statistically significant.


  Results Top


Patient groups had similar exercise capacities (P = 0.3) and body mass index score (P = 0.11). However, the study group was younger (P = 0.005) than control group. According to diagnosis distributions, the majority of cases were bronchiectasis in the study group and interstitial lung disease in the control group. It was seen that the study group waited longer than the control group on the transplantation list (P = 0.03) [Table 1].
Table 1: Comparison of the groups with respect to baseline demographic characteristics, diagnostic distributions, exercise capacities, initial pulmonary, and cardiac functions

Click here to view


When the pre- and post-rehabilitation values of the patients undergoing preoperative PR program were compared, a statistically significant improvement was observed in 6-min walking distance (P = 0.03), dyspnea perception (P = 0.003), and distances recorded in all exercise ergometers (P < 0.05). The comparison of preoperative PR efficacy in terms of exercise capacities and dyspnea perception in the study group was given in [Table 2].
Table 2: The immediate effects of preoperative pulmonary rehabilitation on exercise capacity and dyspnea perception in the study group

Click here to view


The number of intubation days was shorter in study group (mean: 2 days), compared to control group (mean: 3 days) (P = 0.02). The durations of intraoperative anesthesia and total ischemia time were similar in both the groups. There was no significant difference between the duration of stay in ICU, and the mortality rates of the groups are given in [Table 3]. The length of ICU stay was shorter in study group, although it did not reach statistical significance.
Table 3: Comparison of the groups with respect to intra- and post-operative conditions and mortality rates

Click here to view



  Discussion Top


Our study outcomes showed that preoperative PR may shorten time to intubation in patients undergoing LTx. In addition, preoperative PR increases the exercise capacity and improves dyspnea perception.

Organ transplantation is an intervention that saves lives and increases the quality of life in individuals with terminal organ insufficiency.[8] LTx is administered to prolong survival in patients with an advanced pulmonary disease such as chronic obstructive pulmonary disease, cystic fibrosis, idiopathic pulmonary fibrosis, and pulmonary hypertension.[9]

PR in LTx candidates optimizes the physical functions of individuals[10] and facilitates adaptation to the new lung after transplantation and recovery.[11] The clinical and surgical evaluation is a long process.[11] Fifty percent of LTx candidates are being lost or waiting on the waiting list.[12] In a retrospective study[12] conducted a 10-year data search, 103 LTx candidates data were examined. Twenty-three percent of these patients were lost in the waiting period, and 27% were still on waiting lists. The prolongation of the waiting period is a disadvantage for the transplant candidates carrying the potential to worsen their general condition despite optimal medical care. In our study, the mean LTx waiting duration of patients was 124 days in study group and 48 days in control group. The study group was found to wait longer. PR can serve as a bridge until the LTx in the waiting period act as a bridge to the LTx operation.[11]

Preoperative clinical condition may be predictive of postoperative period. A study showed that exercise capacity and resting carbon dioxide in arterial blood values are directly related to the rate of success in LTx.[13] In our study, patient groups were similar in terms of exercise capacity at the baseline. We aimed to have a positive effect on the postoperative process by increasing exercise capacity with exercise training and optimizing the patients' clinical status before the surgery. Another study showed that baseline parameters can affect mortality and hospital stay after surgery, and preoperative PR can decrease ICU days, mechanical ventilation days, and chest tube days.[14] A single-center experience study showed that improvements in posttransplant survival might have been originated from pretransplant PR along with other factors such as better medication and decreased blood (transfusion) needs.[15] Our study showed that pretransplantation PR shorten the time of intubation (posttransplant). In addition, although not statistically significant, the length of ICU stay in study group was shorter which was clinically significant. We thought that this could be affected by the positive effect of aerobic exercise on general clinical status. In addition, we considered that learning breathing exercises prior to surgery could improve compliance with physiotherapy techniques in ICU, and this situation could affect the patient clinical status.

There are some studies indicating that exercise training in LTx in the preoperative period improves postoperative outcomes and reduces the length of stay in the hospital.[16] However, the effect of preoperative PR on intraoperative process has not been sufficiently investigated. In this study, we observed that the preoperative PR group and the nonpreoperative PR group comparisons were similar in terms of intraoperative anesthesia, total ischemia, and ICU stay and also there was no difference between the mortality rates. We could not associate preoperative PR with the intraoperative course. This situation may be associated with relatively small number of patients in our study. Moreover, this situation can be affected by numerous factors including; age, gender, or diagnosis type of LTx. On the other hand, the groups look the same (except age) as the content, they are statistically comparable.

PR plays an important role for the maintenance of physical condition before and after LTx.[17],[18],[19] A systematic review[20] demonstrated that exercise should be included in the regular management of patients for LTx. Some researchers have suggested that the clinical benefits of PR for patients with advanced lung disease make the engagement in a PR program required for patients for LTx in the preoperative time period.[21] In our study, preoperative PR improved fatigue ratio, exercise capacities, and dyspnea perception of the patients preoperatively. We believe that these gains also contribute to the postoperative process.

Limitations of our work

A retrospective study of work, a relatively small number of patients. Further, large-scale, prospective studies are needed to confirm these findings.


  Conclusions Top


Our study results showed that preoperative PR may shorten time to intubation in patients undergoing LTx. In addition, preoperative PR increases the exercise capacity and improves dyspnea perception. Referring preoperative LTx candidates to PR is important in improving the patient's preoperative clinical status, preparing for surgery, and optimizing the postoperative process.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Hill K, Vogiatzis I, Burtin C. The importance of components of pulmonary rehabilitation, other than exercise training, in COPD. Eur Respir Rev 2013;22:405-13.  Back to cited text no. 1
    
2.
Pehlivan E, Turna A, Gurses A, Gurses HN. The effects of preoperative short-term intense physical therapy in lung cancer patients: A randomized controlled trial. Ann Thorac Cardiovasc Surg 2011;17:461-8.  Back to cited text no. 2
    
3.
Vagvolgyi A, Rozgonyi Z, Kerti M, Vadasz P, Varga J. Effectiveness of perioperative pulmonary rehabilitation in thoracic surgery. J Thorac Dis 2017;9:1584-91.  Back to cited text no. 3
    
4.
Saito H, Hatakeyama K, Konno H, Matsunaga T, Shimada Y, Minamiya Y. Impact of pulmonary rehabilitation on postoperative complications in patients with lung cancer and chronic obstructive pulmonary disease. Thorac Cancer 2017;8:451-60.  Back to cited text no. 4
    
5.
Mainini C, Rebelo PF, Bardelli R, Kopliku B, Tenconi S, Costi S, et al. Perioperative physical exercise interventions for patients undergoing lung cancer surgery: What is the evidence? SAGE Open Med 2016;4:2050312116673855.  Back to cited text no. 5
    
6.
ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: Guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002;166:111-7.  Back to cited text no. 6
    
7.
Celli BR, Decramer M, Wedzicha JA, Wilson KC, Agustí A, Criner GJ, et al. An official American Thoracic Society/European Respiratory Society statement: Research questions in COPD. Eur Respir J 2015;45:879-905.  Back to cited text no. 7
    
8.
Grinyó JM. Why is organ transplantation clinically important? Cold Spring Harb Perspect Med 2013;3. pii: a014985.  Back to cited text no. 8
    
9.
Kugler C, Gottlieb J, Warnecke G, Schwarz A, Weissenborn K, Barg-Hock H, et al. Health-related quality of life after solid organ transplantation: A prospective, multiorgan cohort study. Transplantation 2013;96:316-23.  Back to cited text no. 9
    
10.
Pehlivan E, Mutluay F, Balcı A, Kılıç L. The effects of inspiratory muscle training on exercise capacity, dyspnea and respiratory functions in lung transplantation candidates: A randomized controlled trial. Clin Rehabil 2018;32:1328-39.  Back to cited text no. 10
    
11.
Wickerson L, Rozenberg D, Janaudis-Ferreira T, Deliva R, Lo V, Beauchamp G, et al. Physical rehabilitation for lung transplant candidates and recipients: An evidence-informed clinical approach. World J Transplant 2016;6:517-31.  Back to cited text no. 11
    
12.
He WX, Yang YL, Xia Y, Song N, Liu M, Zhang P, et al. Outcomes of chinese patients with end-stage pulmonary disease while awaiting lung transplantation: A Single-center study. Chin Med J (Engl) 2016;129:3-7.  Back to cited text no. 12
    
13.
Takaoka ST, Weinacker AB. The value of preoperative pulmonary rehabilitation. Thorac Surg Clin 2005;15:203-11.  Back to cited text no. 13
    
14.
Szekely LA, Oelberg DA, Wright C, Johnson DC, Wain J, Trotman-Dickenson B, et al. Preoperative predictors of operative morbidity and mortality in COPD patients undergoing bilateral lung volume reduction surgery. Chest 1997;111:550-8.  Back to cited text no. 14
    
15.
Costache V, Chavanon O, St Raymond C, Sessa C, Durand M, Duret J, et al. Dramatic improvement in survival after lung transplantation over time: A single center experience. Transplant Proc 2009;41:687-91.  Back to cited text no. 15
    
16.
Polastri M, Dell'Amore A, Zagnoni G, Nava S. Preoperative physiotherapy in subjects with idiopathic pulmonary fibrosis qualified for lung transplantation: Implications on hospital length of stay and clinical outcomes. J Thorac Dis 2016;8:E264-8.  Back to cited text no. 16
    
17.
Langer D. Rehabilitation in patients before and after lung transplantation. Respiration 2015;89:353-62.  Back to cited text no. 17
    
18.
Candemir I, Ergun P, Kaymaz D, Demir N, Taşdemir F, Sengul F, et al. The efficacy of outpatient pulmonary rehabilitation after bilateral lung transplantation. J Cardiopulm Rehabil Prev 2019;39:E7-12.  Back to cited text no. 18
    
19.
Pehlivan E, Balcı A, Kılıç L, Kadakal F. Preoperative pulmonary rehabilitation for lung transplant: Effects on pulmonary function, exercise capacity, and quality of life; first results in Turkey. Exp Clin Transplant 2018;16:455-60.  Back to cited text no. 19
    
20.
Wickerson L, Mathur S, Brooks D. Exercise training after lung transplantation: A systematic review. J Heart Lung Transplant 2010;29:497-503.  Back to cited text no. 20
    
21.
Rochester CL. Pulmonary rehabilitation for patients who undergo lung-volume-reduction surgery or lung transplantation. Respir Care 2008;53:1196-202.  Back to cited text no. 21
    


    Figures

  [Figure 1]
 
 
    Tables

  [Table 1], [Table 2], [Table 3]



 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Abstract
Introduction
Subjects and Methods
Results
Discussion
Conclusions
References
Article Figures
Article Tables

 Article Access Statistics
    Viewed452    
    Printed41    
    Emailed0    
    PDF Downloaded79    
    Comments [Add]    

Recommend this journal