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REVIEW ARTICLE
Year : 2021  |  Volume : 23  |  Issue : 1  |  Page : 10-13

Current challenges and future scope of nanoparticles in chronic obstructive pulmonary disease


1 Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
2 Department of Physiology, King George's Medical University, Lucknow, Uttar Pradesh, India
3 Division of Biotechnology, Defence Research and Development Establishment, Gwalior, Madhya Pradesh, India

Correspondence Address:
Sarika Pandey
Department of Respiratory Medicine, King George's Medical University, Lucknow - 226 010, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejop.ejop_57_19

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Chronic obstructive pulmonary disease (COPD), characterized by airway inflammation and progressive airflow limitation, is one of the leading causes of mortality worldwide. Bronchodilators, corticosteroids, or antibiotics are used for treatment of COPD, but the drugs are not delivered properly to the target cells or a tissue, which remains a challenge. Nanoparticles (NPs) have gained a tremendous interest in respiratory medicine due to their smaller size, higher surface to volume ratio, and advantages such as targeting effects, patient compliance, and improved pharmacotherapy. Sustained delivery of drugs mediated by NPs to the targeted site is needed to control cell chemotaxis, fibrosis, and chronic obstruction of lungs in COPD. Development of multifunctional biodegradable NPs that are nontoxic and can help in overcoming airway defense will be beneficial in future for COPD.


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